Macrophage inhibitory factor

Function Macrophage inhibitory factor (MIF) is an inflammatory cytokine. MIF is released to the blood stream upon stimulation of white blood cells by bacterial antigens. Relevance MIF plays a role in various solid and hematologic tumors. MIF is overexpressed in various tumors and is suggested to be the molecular link between chronic inflammation and cancer. MIF has a role in skin inflammation, immune response, disease, tumorigenesis and wound healing. MIF has a role in Alzheimer disease and its inhibition may prevent the disease onset. Structural highlights MIF contains two different catalytic sites. A phenylpyruvate tautomerase site is located in the N terminal. A disulfide reductase site is located in the tetrapeptide Cys-Ala-Leu-Cys in position 57-60. The inhibitor binds to the pro-inflammatory tautomerase site.

spinqualitylabelsall models Structure of human macrophage inhibitory factor trimer complex with inhibitor, glycerol and sulfate (PDB entry 2ooh) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D structures of macrophage inhibitory factor3D structures of macrophage inhibitory factor

Updated on 14-April-2016

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• macrophage inhibitory factor
  • 1mif – MIF (mutant) – rat
    
  • 1fim, 1gif, 1gd0, 3djh – hMIF – human
    
  • 1cgq, 1p1g, 4etg, 4eui, 4evg, 4grn, 4gro, 4grp, 4grq, 4grr, 4gru – hMIF (mutant)
    
  • 1mff – mMIF (mutant) – mouse
    
  • 1hfo – MIF – Trichinella spiralis
    
  • 1uiz – MIF – Xenopus laevis
    
  • 2wkb, 2wkf – MIF – Plasmodium berghei
    
  • 3t5s – MIF – Giardia lamblia
    
  • 4gum – MIF (mutant) – rhesus monkey
    
  • 4dh4 – MIF – Toxoplasma gondii
    
• MIF complexes
  • 1mfi, 2gdg – mMIF + inhibitor
    
  • 1ca7 – hMIF + hydroxyphenylpyruvate
    
  • 3ijj – hMIF + hydroxyphenylpyruvate + inhibitor
    
  • 1gcz, 1ljt, 2ooh, 2oow, 2ooz, 3b9s, 3jsf, 3jsg, 3jtu, 3l5p, 3l5r, 3l5s, 3l5t, 3l5u, 3l5v, 3ijg, 4f2k, 3smb, 3smc, 3wnr, 3wns, 3wnt, 4osf, 4p01, 4k9g, 4oyq, 4p0h, 4wr8, 4wrb – hMIF + inhibitor
    
  • 3dji – hMIF + tylenol
    
  • 3ce4 – hMIF + PMSF
    
  • 3hof – hMIF + cafeic acid
    
  • 3u18 – hMIF + Chicago sky blue
    
  • 3rf4, 3rf5 – MIF + inhibitor – Ancylostoma ceylanicum
    
  • 4p7m, 4p7s – MIF + inhibitor – Plasmodium falciparum