Sandbox WWC2

IntroductionIntroduction

Monoamine oxidase A (MAO-A) is an flavoenzyme, encoded in the MAOA gene on the X chromosome, that is present throughout the brain, central nervous system, and stomach. Two isoforms of this enzyme are expressed on the outer surface of the mitochondrial membrane, MAO-A and MAO-B, and both are responsible for the oxidative deamination of various neurotransmitters and dietary amines. Each isoform is characterized by its unique substrate specificity and inhibitor sensitivity (Kaludercic et al.). For example, MAO-A preferentially oxidizes 5-hydroxytryptamine (5-HT), epinephrine, and norepinephrine; while MAO-B prefers phenylethylamine and benzylamine. Both of these enzymes oxidize dopamine, tyramine, and N,N-dimethyltryptamine.

spinqualitylabelsall models Crystal Structure of Human Monoamine Oxidase A with Harmine Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

The , illustrated in the protein image to the right, in conjunction with the color key, below, indicates the directionality of the polypeptide chain.

Amino Terminus

Carboxy Terminus

How many alpha helices are in this structure?

	None
	One
	Four.

Structural highlightsStructural highlights

This is a sample scene created with SAT to by Group, and another to make of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.

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