4zj8

Structures of the human OX1 orexin receptor bound to selective and dual antagonistsStructures of the human OX1 orexin receptor bound to selective and dual antagonists

Structural highlights

4zj8 is a 1 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:	,
Related:	4zjc
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum

Function

[OX1R_HUMAN] Moderately selective excitatory receptor for orexin-A and, with a lower affinity, for orexin-B neuropeptide. Seems to be exclusively coupled to the G(q) subclass of heteromeric G proteins, which activates the phospholipase C mediated signaling cascade (By similarity).

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OCA