Bone morphogenetic protein

Function Bone morphogenetic protein (BMP) are growth factors which can induce formation of bone and cartllage'. Over 20 BMPs are known at present. BMP is part of the Transforming Growth Factor-β (TGF-β) family of proteins. For details on BMP-2 see Student Projects for UMass Chemistry 423 Spring 2012-4. Relevance Recombinant BMP is used in oral surgery and spinal fusion. Disease BMP-7 is involved in chronic kidney disease.

spinqualitylabelsall models Human BMP-2 (grey and green) complex with BMP receptor extracellular domain (yellow and pink) (PDB entry 2qja) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D structures of bone morphogenetic protein3D structures of bone morphogenetic protein

Updated on 22-February-2016

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• Bone morphogenetic protein 1
  • 3edg, 3edh – hBMP protease domain – human
    
• Bone morphogenetic protein 2
  • 3bmp – hBMP
    
  • 1reu – hBMP (mutant)
    
  • 4n1d – hBMP/Nodal
    
  • 4mid – hBMP/activin A
    
  • 1es7, 1rew, 2qj9, 2qja, 2qjb – hBMP + BMP receptor IA
    
  • 3bk3 – hBMP + crossveinless 2
    
  • 2goo, 2h62, 2h64 – hBMP + BMP receptor IA + activin II receptor
    
  • 4uhy, 4uhz, 4ui0, 4ui1 – hBMP C terminal + repulsive guidance molecule
    
  • 4ui2 – hBMP C terminal + repulsive guidance molecule + neogenin
    
• Bone morphogenetic protein 3
  • 2qcq – hBMP
    
• Bone morphogenetic protein 6
  • 2qcw, 2r52, 2r53 – hBMP
    
• Bone morphogenetic protein 7
  • 1bmp, 1lxi – hBMP
    
  • 1m4u – hBMP + noggin
    
  • 1lx5 – hBMP + activin II receptor
    
• Bone morphogenetic protein 9
  • 1zkz, 4mpl – hBMP
    
  • 4ycg, 4yci – BMP - mouse