Ficolin

Function Ficolin (Fic) are defense proteins which belong to the innate immune system and recognize carbohydrate molecules. 3 ficolins were identified in humans L-Fic or ficolin-2, H-Fic or ficolin-3 and M-Fic or ficolin-1. Disease Fn may play a role in inflammatory diseases, apoptosis, lupus, preeclampsia and IgA nephropathy. Structural highlights .

spinqualitylabelsall models Human H-ficolin binding domain trimer complex with Ca+2 ion (PDB code 2j64) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D Structures of Ficolin3D Structures of Ficolin

Updated on 21-February-2016

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• H-ficolin
  • 2j64 - hH-Fic binding domain - human
    
  • 2j5z - hH-Fic binding domain + galactose
    
  • 2j60 - hH-Fic binding domain + fucose
    
  • 2j61 - hH-Fic binding domain + acetyl-glucosamine
    
• L-ficolin
  • 2j3g, 4r9t - hL-Fic binding domain
    
  • 2j0g – hL-Fic binding domain + N-acetyl-mannosamine
    
  • 2j0h - hL-Fic binding domain + acetylcholine
    
  • 4nyt - hL-Fic binding domain + phosphocholine
    
  • 2j0y - hL-Fic binding domain + glucan
    
  • 2j1g, 2j2p - hL-Fic binding domain + acetylcysteine
    
  • 2j3f - hL-Fic binding domain + galactosamine
    
  • 2j3o - hL-Fic binding domain + acetyl-glucosamine
    
  • 4r9j - hL-Fic binding domain + glucosamine sulfate
    
  • 2j3u - hL-Fic binding domain + galactose
    
• M-ficolin
  • 2d39 – hM-Fic fibrinogen-like domain
    
  • 2wnp - hM-Fic fibrinogen-like domain (mutant)
    
  • 2jhh, 2jhm – hM-Fic C terminal
    
  • 2jhi - hL-Mic C terminal + acetyl-galactosamine
    
  • 2jhk - hL-Mic C terminal + acetyl-glucosamine
    
  • 2jhl - hL-Mic C terminal + sialic acid