Neuroligin

File:3be8a.png

Crystal Structure of human Neuroligin 3be8

Neuroligins (NLGN) are a family of postsynaptic proteins which bind to the presynaptic Neurexin (NRXN) to form a complex which attaches neurons. In humans the NLGN family contains 4 to 5 members that are numbered 1, 2, 3, 4X and 5 or 4Y. See Neurodevelopmental Disorders.

For Structural Analysis of Neuroligin, See: Neuroligin-Neurexin Interaction

3D Structures of Neuroligin3D Structures of Neuroligin

16-February-2016

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• Neuroligin
  • 3bl8 - mNLGN-2 cholinesterase domain – mouse
    
  • 3be8 - hNLGN-4 cholinesterase domain – human
    
  • 3bix - rNLGN-1 cholinesterase domain - rat
    
• Neuroligin+neurexin
  • 2xb6, 2wqz – hNLGN-4 cholinesterase domain+NRXN-1β LNS domain
    
  • 3b3q - mNLGN-4 cholinesterase domain+NRXN-1β LNS domain
    
  • 3biw - rNLGN-1 cholinesterase domain+NRXN-1β LNS domain
    
  • 3vkf - rNLGN-1 cholinesterase domain + bNRXN-1β LNS domain