User:Ann Taylor/Sandbox Trypsin

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Revision as of 18:34, 12 February 2016 by Ann Taylor (talk | contribs) (New page: ==The Mechanism of Trypsin== <StructureSection load='1agg' size='340' side='right' caption='Acyl intermediate of trypsin catalyzed hydrolysis' scene=''> One of the ways we know about the ...)
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The Mechanism of TrypsinThe Mechanism of Trypsin


One of the ways we know about the mechanism of enzymes is through the use of xray crystallography structures of trapped intermediates or inhibitors bound to enzymes. In a paper by Radisky and Koshland[1], an acyl intermediate of trypsin (PDB code 2AGG was characterized.




Acyl intermediate of trypsin catalyzed hydrolysis

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ReferencesReferences

  1. ↑ Radisky ES, Lee JM, Lu CJ, Koshland DE Jr. Insights into the serine protease mechanism from atomic resolution structures of trypsin reaction intermediates. Proc Natl Acad Sci U S A. 2006 May 2;103(18):6835-40. Epub 2006 Apr 24. PMID:16636277
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