5eg9

The cap binding site of influenza virus protein PB2 as a drug targetThe cap binding site of influenza virus protein PB2 as a drug target

Structural highlights 5eg9 is a 2 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Related: 5eg7, 5eg8 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum Function [PB2_I02A6] Plays an essential role in transcription initiation and cap-stealing mechanism, in which cellular capped pre-mRNAs are used to generate primers for viral transcription. Binds the cap of the target pre-RNA which is subsequently cleaved after 10-13 nucleotides by PA. Plays a role in the initiation of the viral genome replication and modulates the activity of the ribonucleoprotein (RNP) complex. In addition, participates in the inhibition of type I interferon induction through interaction with the host mitochondrial antiviral signaling protein MAVS.[UniProtKB:P03428]

spinqualitylabelsall models 5eg9, resolution 2.30Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image