Epoxide hydrolase

Function Epoxide hydrolase (EH) converts epoxides to trans-dihydrodiols which are excreted from the body. Thus, EH acts as a detoxification agent. Epoxides are formed from degradation of aromatic compounds. Bifunctional EH 2 or soluble EH (SEH) is a bifunctional enzyme with the C-terminal domain having EH activity and the N-terminal domain having lipid phosphatase activity. Limonene-1,2-epoxide hydrolase catalyzes the conversion of limonene-1,2-epoxide to limonene-1,2-diol . Disease Inhibitors of Mycobacterium tuberculosis EH such as urea derivatives, are used as anti-tuberculosis drugs. The valpromide inhibitor of EH is used as anti-epileptic drug. Soluble EH plays a role in several diseases including cardiovascular ones and is a drug target for their therapy . Structural highlights . (PDB code 5alf).

spinqualitylabelsall models Human soluble epoxide hydrolase complex with imidazole derivative inhibitor (PDB code 5alf) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D Structures of epoxide hydrolase3D Structures of epoxide hydrolase

Updated on 10-February-2016

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• Epoxide hydrolase
  • 2e3j – EH B – Mycobacterium tuberculosis
    
  • 1qo7, 3g02 – AnEH (mutant) – Aspergillus niger
    
  • 2cjp – pEH I – potato
    
  • 3cxu – pEH (mutant)
    
  • 4i19, 4qa9 – EH – Streptomyces carzinostaticus
    
• Soluble epoxide hydrolase
  • 1s8o, 3i1y, 3i28, 3koo, 5ahx – hSEH – human
    
  • 1cqz – mSEH – mouse
    
  • 4nzz – BmSEH – Bacillus megaterium
    
  • 4inz – BmSEH (mutant)
    
  • 1ehy – SEH – Agrobacterium tumefaciens
    
• Epoxide hydrolase complex with inhibitor
  • 3g0i – AnEH + valpromide
    
  • 3rga – SlEH + oxazolidinone inhibitor – Streptomyces lasaliensis
    
  • 4rzm – SlEH + lasalocid A
    
• Soluble epoxide hydrolase complex with inhibitor
  • 1vj5, 1zd2, 1zd3, 1zd4, 1zd5, 3wk4, 4c4x, 4c4y, 4c4z, 5ai5, 5akz, 5ali – hSEH + urea derivative inhibitor
    
  • 1cr6, 1ek1, 1ek2 – mSEH + urea derivative inhibitor
    
  • 3otq, 3wk7, 4y2j, 4y2s, 4y2v, 5ak4, 5akh, 5aki, 5alk, 5alq, 5alv, 5aly – hSEH + pyrazole inhibitor
    
  • 5akj, 5alf, 5als – hSEH + imidazole inhibitor
    
  • 5akk, 5ald, 5aln, 5alo, 5alw, 5am4 – hSEH + indolone inhibitor
    
  • 5akx, 5aky – hSEH + indazole inhibitor
    
  • 3wk5, 3wk6, 3wk8, 3wk9, 3wkc, 5ai8, 5aic, 5akg, 5alg – hSEH + thiazole derivative inhibitor
    
  • 3ans, 3ant – hSEH + synthetic inhibitor
    
  • 3pdc, 5ale – hSEH catalytic domain + benzoxazole inhibitor
    
  • 4jnc, 5alx – hSEH catalytic domain + carboxamide inhibitor
    
  • 4x6x, 4x6y – hSEH catalytic domain + cyclopropane inhibitor
    
  • 4hai, 3wka, 4ocz, 4od0, 5ake, 5alh, 5am1 – hSEH + piperidine derivative inhibitor
    
  • 4y2p, 4y2q, 5ai4, 5ak5, 5ak6, 5alt, 5am5 – hSEH + pyridine derivative inhibitor
    
  • 4y2r – hSEH + piperazine derivative inhibitor
    
  • 5akl, 5alm, 5am0 – hSEH + pyrrolidine derivative inhibitor
    
  • 4y2t, 5aib – hSEH + benzyloxy derivative inhibitor
    
  • 3wkb – hSEH + quinoxaline derivative inhibitor
    
  • 4y2u, 5ai6, 5alj, 5alr, 5am2 – hSEH + quinoline derivative inhibitor
    
  • 4y2x, 5alu, 5alz – hSEH + adamantanyl derivative inhibitor
    
  • 4y2y – hSEH + etylmethyamine derivative inhibitor
    
  • 3wkd, 5alp – hSEH + morpholine derivative inhibitor
    
  • 3wke, 5am3 – hSEH + carbamoyl derivative inhibitor
    
  • 4j03 – hSEH + fulvestrant
    
  • 5ai0 – hSEH + phenyl oxadiazolamine inhibitor
    
  • 5ai9 – hSEH + phenol derivative inhibitor
    
  • 5aia – hSEH + benzoate derivative inhibitor
    
  • 5ak3 – hSEH + indan-amine derivative inhibitor
    
  • 5all – hSEH + cyclohexyl methanol inhibitor
    
  • 4o08 – BmSEH + phenoxy acetamide inhibitor
    
• Soluble epoxide hydrolase complex with product
  • 4io0 – BmSEH + naphthyloxy propane diol
    
• Limonene-1,2-epoxide hydrolase
  • 1nww – ReEH – Rhodococcus erythropolis
    
  • 4r9k, 4r9l, 4xbx, 4xdw – ReEH (mutant)
    
  • 1nu3 – ReEH + valpromide
    
  • 4xbt, 4xdv – ReEH (mutant) + cyclohexanediol
    
  • 4xby – ReEH (mutant) + cyclopentene oxi