Ets1

Function Ets1 (E26 Transformation-Specific) is a proto-oncogene translation factor. Ets1 contributes to the regulation of cellular differentiation . Relevance Ets1 promotes invasive behavior in endothelial cells, smooth muscle cells and epithelial cancer cells. Structural highlights Ets1 contains an ETS domain (residues 332-415) which is a helix-turn-helix DNA-binding domain which recognizes the sequence GGAA/T. The ETS domain is flanked by autoinhibitory domains. At the N-terminal, Ets1 contains a pointed domain (PNT) (residues 54-135) and a MAP kinase phosphorylation domain. PNT domain is related to SAM domains and contains 4 α-helices.

spinqualitylabelsall models Structure of mouse Ets1 ETS domain (green) complex with paired box protein Pax5 (grey) and MB-1 promoter DNA (PDB code 1mdm). Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D Structures of Ets13D Structures of Ets1

Updated on 20-January-2016

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• Ets1
  • 1md0 – mETS1 ETS domain - mouse
    
  • 1r36 – mETS1 ETS and autoinhibitory domains - NMR
    
  • 2jv3, 2kmd – mETS1 PNT domain - NMR
    
  • 1gvj – hETS1 ETS and autoinhibitory domains - human
    
• Ets1 binary complexes
  • 2nny – hETS1 residues 280-441 + DNA
    
  • 3mfk – hETS1 residues 280-441 + stromelysin promoter DNA
    
  • 3ri4 – hETS1 residues 280-441 + TCR α promoter DNA
    
  • 2stt, 2stw – hETS1 ETS domain + DNA - NMR
    
  • 1k79, 1k7a – mETS1 ETS domain + DNA containing GGAA - mouse
    
• Ets1 ternary complexes
  • 1mdm – mETS1 ETS domain + paired box protein Pax5 + MB-1 promoter DNA
    
  • 1k78 – hETS1 ETS domain + paired box protein Pax5 + MB-1 promoter DNA - NMR
    
  • 4l0y, 4l0z, 4l18 – hETS1 residues 296-441 + TCR α promoter DNA + RunT-related transcription factor
    
  • 4lg0 – hETS1 residues 280-441 + cadherin promoter DNA + forkhead box protein