Monocyte chemoattractant protein

Function Monocyte chemoattractant protein (MCP) belongs to the superfamily of chemokines, which are proteins involved in immunoregulatory and inflammatory processes. The superfamily can be subdivided into 4 smaller groups, depending on the N-ter arangment of the cysteines. The MCP-1 is also known as chemokine (C-C motif) ligand or CCL2 or: - small inducible cytokine A2 (SCYA2) - MCAF - GDCF-2 - SMC-CF - HSMCR30 - MGC9434 - GDCF-2 - HC11. Disease CCL2 is implicated in several diseases like psoriasis, rheumatoid arthritis and atherosclerosis. Relevance CCL2 is overexpressed in epilepsy, brain ischemia, Alzheimer's disease, EAE and traumatic brain injury. Structural highlights CCL2 is part of the C-C motif group because of the covalent bond made between 2 of the 4 cysteines of the N terminal domain.

spinqualitylabelsall models Monocyte chemoattractant protein 1 complex with sulfate (PDB code 1dok) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D structures of 6-aminohexanoate-dimer hydrolase3D structures of 6-aminohexanoate-dimer hydrolase

Updated on 05-January-2016

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• Monocyte chemoattractant protein 1
  • 1dok, 1dol – hMCP-1 (mutant) - human
    
  • 3ifd – hMCP-1
    
  • 1dom, 1don – hMCP-1 - NMR
    
  • 1ml0, 2nz1 – hMCP-1 (mutant) + M3 protein
    
  • 2bdn – hMCP-1 + antibody
    
  • 4dn4 – hMCP-1 (mutant) + antibody
    
  • 4zk9 – hMCP-1 + chemokine binding protein
    
  • 4r8i – hMCP-1 + RNA
    
• Monocyte chemoattractant protein 2
  • 1esr – hMCP-2 (mutant)
    
• Monocyte chemoattractant protein 3
  • 1ncv, 1bo0 – hMCP-3 - NMR
    
  • 4zkc – hMCP-3 + chemokine binding protein
    
• Monocyte chemoattractant protein 4
  • 2ra4 – hMCP-4
    

ReferencesReferences

https://fr.wikipedia.org/wiki/CCL2 http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl?pdbcode=1DOK http://www.uniprot.org/uniprot/P13500#interaction