Dual specificity phosphatase

FunctionFunction

Dual specificity phosphatase (DUSP) is a phosphatase which acts on tyrosine, serine or threonine residues. There are several DUSP enzymes in mammals sharing a common catalytic mechanism. The DUSP include:
• Slingshot phosphatase
• Phosphatase of regenerating liver (PRL)
• Cdc14
• Cdc25
• PTEN
• Myotubularin dephosphorylates phosphadinylinositol 3-phosphate and phosphadinylinositol (3,5)-bi-phosphate
• MAPK phosphatase see MAP kinase phosphatase

RelevanceRelevance

Cdc25A and Cdc25B are overexpressed in several types of cancers and their inhibitors are being tested as chemotherapeutic agents.
PTEN gene is mutated with high frequency in a variety of human cancers.
Phosphatase of regenerating liver is overexpressed in several types of cancers.

DiseaseDisease

Myotubularin mutations are responsible for the hereditary motor disease Charcot-Marie-Tooth disease.

3D structures of dual specificity phosphatase3D structures of dual specificity phosphatase

Updated on 03-January-2016

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• Slingshot phosphatase (SSH)
  • 2nt2 – hSSH-2L catalytic domain - human
    
• Phosphatase of regenerating liver (PRL)
  • 1xm2 – hPRL-1 (mutant)
    
  • 1zck, 1x24 – rPRL-1 - rat
    
  • 1zcl – rPRL-1 (mutant)
    
  • 1r6h, 1v3a, 2mbc – hPRL-3 - NMR
    
• Cdc14
  • 1ohc, 1ohd – hCdc14B2 core domain
    
  • 1ohe – hCdc14B2 core domain + peptide
    
• Cdc25
  • 1qb0, 1cwr, 1cws, 1cwt, 1ym9, 1ymd, 1ymk, 1yml, 1ys0, 2uzq – hCdc25B catalytic domain
    
  • 2a2k, 2ifd, 2ifv – hCdc25B catalytic domain (mutant)
    
• Phosphoinositide phosphatase PTEN
  • 1d5r – hPTEN (mutant)
    
• Myotubularin-related protein (MTMR)
  • 1zvr – hMTMR2 PH-gram and phosphatase domains (mutant)
    
  • 1zsq - hMTMR2 PH-gram and phosphatase domains (mutant) + phosphatidylinositol 3-phosphate
    
  • 1m7r, 1lw3 - hMTMR2 PH-gram and phosphatase domains (mutant) + phosphate
    
  • 2yf0 – hMTMR6
    
• MAPK phosphatase see MAP kinase phosphatase