CREB-binding protein

File:1kbh.png

Crystal structure of CREB-binding protein bromodomain (green) complex with nuclear receptor coactivator (grey) 1kbh

FunctionFunction

CREB-binding protein (CBP) is a transcription activator. CREB is cAMP response element-binding protein which is a cellular transcription factor which binds to DNA and regulates transcription. CBP acetylates histones. It binds to phosphorylated CREB and enhances its activity.

DiseaseDisease

Mutations in CBP cause Rubinstein-Taybi syndrome.

Structural highlightsStructural highlights

CBP contains several domains. Among them the lysine recognition bromodomain; domains KIX, TAZ1 and TAZ2 which bind sequences spanning the transactivation domain of transcription factor p53; IBiD which binds the interferon response; ZZ is a zinc-binding motif; CH1 (Cys- and His-rich region 1) interacts with the N-terminal of p73.

3D Structures of CREB-binding protein3D Structures of CREB-binding protein

Updated on 15-December-2015

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• CBP
  • 4i9o – mCBP GACKIX domain (mutant) - mouse
    
  • 1f81 – mCBP TAZ2 domain - NMR
    
  • 1u2n – mCBP TAZ1 domain - NMR
    
  • 1jjs – mCBP IBiD domain - NMR
    
  • 1liq – mCBP CH1 domain - NMR
    
  • 1tot – mCBP ZZ domain – NMR
    
  • 2kkj – mCBP nuclear coactivator binding domain - NMR
    
  • 1wo3, 1wo4, 1wo5, 1wo6, 1wo7 – hCBP zinc finger domain (mutant) – human - NMR
    
  • 2d82 – hCBP bromodomain - NMR
    
  • 3dwy – hCBP bromodomain
    
  • 3p1c, 3p1d, 3p1e, 3p1f, 3svh, 4a9k – hCBP bromodomain + small molecule
    
  • 2l84, 2l85 – hCBP bromodomain + small molecule - NMR
    
• CBP complex with protein
  • 1kbh – hCBP + nuclear receptor coactivator - NMR
    
  • 1zoq – hCBP + interferon regulatory factor 3
    
  • 2c52 – mCBP residues 2059-2117 + nuclear receptor coactivator - NMR
    
  • 1r8u – mCBP TAZ1 domain + P300-interacting transactivator - NMR
    
  • 1l8c – mCBP TAZ1 domain + hypoxia-inducible factor 1α - NMR
    
  • 2lww - mCBP TAZ1 domain + nuclear transcription factor RELA – NMR
    
  • 2ka6 – mCBP TAZ2 domain + STAT1-TAD - NMR
    
  • 2ka4 – mCBP TAZ2 domain + STAT2-TAD - NMR
    
  • 1kdx – mCBP KIX domain + CREB kinase inducible domain - NMR
    
  • 2kje – hCBP TAZ2 domain + adenoviral E1A peptide - NMR
    
  • 1jsp – hCBP bromodomain + p53 peptide - NMR
    
  • 2l14 – mCBP nuclear coactivator binding domain + p53 peptide - NMR
    
  • 1sb0 – mCBP KIX domain + protein c-Myb – NMR
    
  • 2agh – mCBP KIX domain + protein c-Myb + zinc finger protein HRX – NMR
    
  • 2lqh, 2lqi – mCBP KIX domain + forkhead box O3 – NMR
    
  • 2kwf – hCBP KIX domain + transcription factor 4 – NMR
    
  • 2lxs, 2lxt – hCBP KIX domain + histone methyltransferase MLL peptide – NMR
    
  • 2rny – hCBP bromodomain + histone H3 peptide - NMR
    
  • 4n3w, 4n4f - hCBP bromodomain + histone H4 peptide
    
  • 4nr4, 4nr5, 4nr6, 4nr7, 4nyv, 4nyw, 4nyx- hCBP bromodomain + ligand