Core-binding factor

Function Core-binding factor (CBF) is a heterodimeric transcription factor which is composed of α chain which binds DNA and a regulatory β chain. CBF binds to various enhancers and promoters including murine leukemia virus and polyomavirus enhancer. Disease Mutations in CBF β are implicated in breast cancer. Rearrangements of CBF α and β genes are implicated in acute myeloid leukemia. Structural highlights CBF α contains a DNA-binding runt domain (residues 50-177).

spinqualitylabelsall models Human CBFα runt domain (grey and pink) complex with CBFβ heterodimerization domain (green and yellow) and DNA (PDB code 1h9d) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D Structures of core-binding factor3D Structures of core-binding factor

Updated on 14-December-2015

{"openlevels":0}

• Core-binding factor α

• • 1ean, 1ljm – hCBFα runt domain - human
    
  • 1cmo – hCBFα runt domain (mutant) - NMR
    
  • 1co1 – hCBFα runt domain - NMR
    
  • 1eao, 1eaq, 2j6w – mCBFα runt domain (mutant) - mouse
    
  • 1hjc – mCBFα runt domain + DNA
    
  • 1hjb – mCBFα runt domain + hEBP β + DNA
    
  • 4l0y, 4l0z, 4l18, 4wu1 – mCBFα runt domain + hETS1 + DNA
    
• Core-binding factor α+β

• • 1e50 – hCBFα runt domain + hCBFβ heterodimerization domain
    
  • 1h9d – hCBFα runt domain + hCBFβ heterodimerization domain + DNA
    
  • 1io4 – mCBFα runt domain + mCBFβ core domain + hEBP β + DNA
    
  • 3wts – mCBFα runt domain (mutant) + mCBFβ heterodimerization domain + hETS1 + DNA
    
  • 3wtt, 3wtu, 3wtx, 3wty, 3wtv, 3wtw – mCBFα residues 60-263 (mutant) + mCBFβ heterodimerization domain + hETS1 + DNA