DNA Polymerase in Thermococcus gorgonarius

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This Sandbox is Reserved from September 14, 2021, through May 31, 2022, for use in the class Introduction to Biochemistry taught by User:John Means at the University of Rio Grande, Rio Grande, OH, USA. This reservation includes 5 reserved sandboxes (Sandbox Reserved 1590 through Sandbox Reserved 1594).
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DNA PolymeraseDNA Polymerase

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You may include any references to papers as in: the use of JSmol in Proteopedia [1] or to the article describing Jmol [2] to the rescue.[2]

Function

DNA polymerase has an important role in the development of life. DNA polymerase is an enzyme, which synthesizes new stands of DNA from preexisting DNA. It does this by adding one nucleotide at a time to the 3’ end of a growing strand. The new DNA strands are always synthesized from 5’ to the 3’ direction. (GENETICS BOOK) Each time a cell divides, DNA polymerase duplicates all of the cell’s DNA, and the cell passes one copy of DNA to each daughter cell. DNA polymerase roughly makes only one mistake every billion bases. The binding of cytosine to guanine and adenine to thymine help make the replication on DNA polymerase easier, but an extra step of proofreading and cutting out mismatched bases after replication is the reason why DNA polymerase is the most accurate enzyme. (http://www.rcsb.org/pdb/101/motm.do?momID=3)

Disease

http://tools.niehs.nih.gov/polg/

Relevance

Structural highlights

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DNA Polymerase-Beta

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ReferencesReferences

  1. ↑ Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
  2. ↑ 2.0 2.1 Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA, Kayla Briley, Michal Harel, Jaime Prilusky
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