CD3

spinqualitylabelsall models Structure of human CD3 extracellular domain (green) complex with antibody light chain (cyan) and heavy chain (red) (PDB entry 1sy6) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

FunctionFunction

CD3 (or Cluster of Differentiation 3) is a T-cell co-receptor. The CD3 is composed of γ, δ and two ε chains. These 4 chains associate with the T-cell receptor (TCR) and a ζ chain to form an activation signal in T lymphocytes. CD3 assembles as 3 pairs of dimers: εγ, εδ and ζζ. The intracellular domain of CD3 contains a single Immunorecetor Tyrosine-based Activation Motif (ITAM).

• (PDB entry 1sy6).

RelevanceRelevance

Drugs which bind to CD3 are tested as immunorepressants. </StructureSection>

3D structures of CD33D structures of CD3

Updated on 29-November-2015

{"openlevels":0}

• CD3 ε chain
  • 1a81 – hCD3 ITAM + Syk kinase – human
    
  • 2jxb – hCD3 domain SH3-1
    
  • 2k4f – mCD3 ITAM – mouse - NMR
    
  • 3r08 – mCD3 extracellular domain + antibody
    
  • 2mim – CD3 – chicken
    
• CD3 εγ dimer
  • 1jbj – hCD3 extracellular domain - NMR
    
  • 1sy6 – hCD3 extracellular domain + antibody
    
• CD3 εδ dimer
  • 1xiw – hCD3 extracellular domain + antibody
    
  • 1xmw – mCD3 extracellular domain ε/sCD3 extracellular domain δ – sheep
    
• CD3 ζ chain
  • 1ygr, 2oq1 – hCD3 ITAM + CD45 protein tyrosine phosphatase
    
  • 3ik5, 3ioz – hCD3 ITAM + NEF
    
  • 2hac – hCD3 transmembrane domain - NMR