CD59

<StructureSection load='4bik' size='350' side='right' caption='Structure of human CD59 extracellular domain (green and yellow) complex with intermedilysin (grey and pink) (PDB entry 4bik)' scene=>

FunctionFunction

CD59 (Cluster of Differentiation 59) is a protein which attaches to host cells via a GPI anchor. CD59 can prevent the formation of complement membrane attack complex via binding to complement C8 or C9.

RelevanceRelevance

HIV, vaccinia and cytomegalovirus incorporate human CD59 into their envelope thus preventing their lysis by complement.

DiseaseDisease

Mutations in CD59 causes disease involving thrombosis.

3D structures of CD593D structures of CD59

Updated on 24-November-2015

1erg, 1erh, 1cdq, 1cdr, 1cds – hCD59 extracellular domain – human - NMR
2ofs, 2j8b, 2uwr, 2ux2 – hCD59 extracellular domain
4bik – hCD59 extracellular domain + intermedilysin