Calcium/Calmodulin-dependent protein kinase

Function Ca2+/Calmodulin dependent protein kinase (CaMK) are activated by elevation of Ca+2 and calmodulin concentration to phosphorylate Ser and Thr. CaMKI is a specialized CaM kinase. CaMKII is multifunctional kinase. CaMKIII phosphorylates eukaryotic elongation factor 2. CASK is a membrane associated CaMK. DAPK is a death-associated CaMK which protects cells from some programmed cell death. For details see Calcium-dependent protein kinase. Structural highlights CAMKII contains an N-terminal catalytic domain which binds ATP and substrate protein, regulatory domain (CBD) and association domain (ASD). DAPK contains a regulatory (RD) and autoinhibitory (AD) domains. The activity of human CamKII is regulated by autophosphorylation of Thr 286 and Thr 305.

spinqualitylabelsall models Human CamKII subunit α kinase domain complex with indirubin (PDB code 2vz6) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D Structures of Ca²⁺/Calmodulin dependent protein kinase3D Structures of Ca2+/Calmodulin dependent protein kinase

Updated on 17-November-2015

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• CaMKI – specialized CaM kinase
  • 1a06 – rCaMK - rat
    
  • 3nyv, 3n51, 3i7b, 3i7c, 3hzt – TgCaMK + inhibitor – Toxoplasma gondii
    
  • 3ku2, 3i79 - TgCaMK
    
  • 3khe – TgCaMK residues 345-535 + Ca
    
  • 3hx4 – TgCaMK+Ca
    
  • 3dxn, 3is5 – TgCaMK kinase domain + Ca
    
  • 3mwu – CpCaMK (mutant)+ inhibitor + Ca – Cryptosporidium parvum
    
  • 3ncg - CpCaMK + inhibitor + Ca
    
  • 3igo - CpCaMK +Ca
    
  • 3hko - CpCaMK kinase domain residues 125-452 + Zn
    
  • 2qg5, 3dfa – CpCaMK kinase domain
    
  • 3f3z – CpCaMK kinase domain+indirubin_E804
    
  • 2aao – CaMK C terminal + Ca – Arabidopsis thaliana
    
  • 1s6j, 1s6i – sCaMK α residues 329-402 + Ca – soybean - NMR
    
  • 2jam - hCaMKI kinase domain +peptides - human
    
• CASK – membrane-associated CaMK
  • 3mfr – hCASK CBD
    
  • 3mfs – hCASK+AMPPNP
    
  • 3mft – hCASK+Mn
    
  • 3c0g – hCASK kinase domain
    
  • 3c0h - hCASK kinase domain+AMPPNP
    
  • 3c0i - hCASK kinase domain+AMP
    
  • 3mfu - hCASK+AMPPNP+Mn
    
• DAPK – death-associated CaMK
  • 2x0g – hDAPK RD+AD+CaM
    
  • 2cke – hDAPK+inhibitor
    
• CaMKII – multifunctional CaM kinase
  • 2vz6 - hCaMKII α + indirubin-E804
    
  • 3bhh - hCaMKII β
    
  • 2zv2 – hCaMKII β +STO-609
    
  • 2v7o - hCaMKII γ
    
  • 2ux0 - hCaMKII γ (mutant)
    
  • 2wel - hCaMKII δ +CaM
    
  • 2w2c - hCaMKII δ oligomerization domain
    
  • 2vn9 - hCaMKII δ
    
  • 2jc6 - hCaMKII δ
    
  • 1hkx - mCaMKII α - mouse
    
  • 3gp2 – cCaMKII δ +CaM – chicken
    
  • 3kk8, 3kk9 – CeCaMKII – Caenorhabditis elegans
    
  • 3kl8 – CeCaMKII (mutant)+inhibitor
    
  • 3ksp – CaMKII ASD – Exiguobacterium sibiricum
    
  • 3pm8 – PfCaMKII CBD + Ca – Plasmodium falciparum
    
  • 4mvf – PfCaMKII + Ca + staurosporine
    
• CaMKIII
  • 3lij – CpCaMKIII +Ca
    
  • 3l19, 3hko – CpCaMKIII CBD + Ca
    
  • 3k21 – PfCaMKIII C terminal + Ca
    
  • 3jwq – CaMKIII C terminal + Ca – Plasmodium berhei
    
  • 3o4y – CaMKIII C terminal + Ca – Plasmodium vivax
    
• CaMKIV
  • 2w4o – hCaMKIV+inhibitor
    
  • 4rgj – PfCaMKIV
    
  • 4qox – PfCaMKIV + Mg
    

ReferencesReferences

See Calcium-dependent protein kinase