FunctionFunction
Ca2+/Calmodulin dependent protein kinase (CaMK) are activated by elevation of Ca+2 and calmodulin concentration to phosphorylate Ser and Thr.
- CaMKI is a specialized CaM kinase.
- CaMKII is multifunctional kinase.
- CASK is a membrane associated CaMK.
- DAPK is a death-associated CaMK which protects cells from some programmed cell death.
Structural highlightsStructural highlights
CAMKII contains an N-terminal catalytic domain which binds ATP and substrate protein, regulatory domain (CBD) and association domain (ASD). DAPK contains a regulatory (RD) and autoinhibitory (AD) domains.
3D Structures of Ca2+/Calmodulin dependent protein kinase3D Structures of Ca2+/Calmodulin dependent protein kinase
Updated on 15-November-2015
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- CaMKI – specialized CaM kinase
- 1a06 – rCaMK - rat
- 3nyv, 3n51, 3i7b, 3i7c, 3hzt – TgCaMK + inhibitor – Toxoplasma gondii
- 3ku2, 3i79 - TgCaMK
- 3khe – TgCaMK residues 345-535 + Ca
- 3hx4 – TgCaMK+Ca
- 3dxn, 3is5 – TgCaMK kinase domain + Ca
- 3mwu – CpCaMK (mutant)+ inhibitor + Ca – Cryptosporidium parvum
- 3ncg - CpCaMK + inhibitor + Ca
- 3igo - CpCaMK +Ca
- 3hko - CpCaMK kinase domain residues 125-452 + Zn
- 2qg5, 3dfa – CpCaMK kinase domain
- 3f3z – CpCaMK kinase domain+indirubin_E804
- 2aao – CaMK C terminal + Ca – Arabidopsis thaliana
- 1s6j, 1s6i – sCaMK α residues 329-402 + Ca – soybean - NMR
- CASK – membrane-associated CaMK
- 3mfr – hCASK CBD – human
- 3mfs – hCASK+AMPPNP
- 3mft – hCASK+Mn
- 3c0g – hCASK kinase domain
- 3c0h - hCASK kinase domain+AMPPNP
- 3c0i - hCASK kinase domain+AMP
- 3mfu - hCASK+AMPPNP+Mn
- DAPK – death-associated CaMK
- 2x0g – hDAPK RD+AD+CaM
- 2cke – hDAPK+inhibitor
- CaMKII – multifunctional CaM kinase
- 2vz6 - hCaMKII α chains A, B+ indirubin-E804
- 2zv2 – hCaMKII+STO-609
- 2wel - hCaMKII δ chain D+CaM
- 2w2c - hCaMKII δ chain ASD
- 2vn9 - hCaMKII δ chains A-B
- 3bhh - hCaMKII β chains A-D
- 2v7o - hCaMKII γ chain A
- 2ux0 - hCaMKII γ (mutant) chains A-F
- 2jam - hCaMKI γ+peptides
- 2jc6 - hCaMKII δ chains A,C
- 1hkx - mCaMKII α chains A-N ASD - mouse
- 3gp2 – cCaMKII δ chain B+CaM – chicken
- 3kk8, 3kk9 – CeCaMKII – Caenorhabditis elegans
- 3kl8 – CeCaMKII (mutant)+inhibitor
- 3ksp – CaMKII ASD – Exiguobacterium sibiricum
- 3pm8 – PfCaMKII CBD + Ca – Plasmodium falciparum
- 4mvf – PfCaMKII + Ca + staurosporine
- CaMKIII
- 3lij – CpCaMKIII +Ca
- 3l19, 3hko – CpCaMKIII CBD + Ca
- 3k21 – PfCaMKIII C terminal + Ca
- 3jwq – CaMKIII C terminal + Ca – Plasmodium berhei
- 3o4y – CaMKIII C terminal + Ca – Plasmodium vivax
- CaMKIV
- 2w4o – hCaMKIV+inhibitor
- 4rgj – PfCaMKIV
- 4qox – PfCaMKIV + Mg
See alsoSee also