Calcium/Calmodulin-dependent protein kinase

FunctionFunction

Ca2+/Calmodulin dependent protein kinase (CaMK) are activated by elevation of Ca+2 concentration to phosphorylate Ser and Thr.

• CaMKI is a specialized CaM kinase.
  
• CaMKII is multifunctional kinase.
  
• CASK is a membrane associated CaMK.
  
• DAPK is a death-associated CaMK which protects cells from some programmed cell death.

Structural highlightsStructural highlights

CAMKII contains an N-terminal catalytic domain, regulatory domain (CBD) and association domain (ASD). DAPK contains a regulatory (RD) and autoinhibitory (AD) domains.

3D Structures of Ca²⁺/Calmodulin dependent protein kinase3D Structures of Ca2+/Calmodulin dependent protein kinase

Updated on 15-November-2015

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• CaMKK – CaM kinase kinase
  • 1iq5 – CeCaMK CBD+XlCaM – Xenopus laevis
    
• CaMKI – specialized CaM kinase
  • 1mxe – rCaMKI CBD+CaM – rat
    
  • 1ckk – rCaMK CBD chain B+XlCaM
    
  • 1a06 – rCaMK chain A
    
• CASK – membrane-associated CaMK
  • 3mfr – hCASK CBD – human
    
  • 3mfs – hCASK+AMPPNP
    
  • 3mft – hCASK+Mn
    
  • 3c0g – hCASK kinase domain
    
  • 3c0h - hCASK kinase domain+AMPPNP
    
  • 3c0i - hCASK kinase domain+AMP
    
  • 3mfu - hCASK+AMPPNP+Mn
    
• DAPK – death-associated CaMK
  • 2x0g – hDAPK RD+AD+CaM
    
  • 2cke – hDAPK+inhibitor
    
• CaMKII – multifunctional CaM kinase
  • 2vz6 - hCaMKII α chains A, B+ indirubin-E804
    
  • 2zv2 – hCaMKII+STO-609
    
  • 2wel - hCaMKII δ chain D+CaM
    
  • 2w2c - hCaMKII δ chain ASD
    
  • 2vn9 - hCaMKII δ chains A-B
    
  • 3bhh - hCaMKII β chains A-D
    
  • 2v7o - hCaMKII γ chain A
    
  • 2ux0 - hCaMKII γ (mutant) chains A-F
    
  • 2jam - hCaMKI γ+peptides
    
  • 2jc6 - hCaMKII δ chains A,C
    
  • 1hkx - mCaMKII α chains A-N ASD - mouse
    
  • 3gp2 – cCaMKII δ chain B+CaM – chicken
    
  • 3kk8, 3kk9 – CeCaMKII – Caenorhabditis elegans
    
  • 3kl8 – CeCaMKII (mutant)+inhibitor
    
  • 3ksp – CaMKII ASD – Exiguobacterium sibiricum
    
• CaMKIV
  • 2w4o – hCaMKIV+inhibitor
    

See alsoSee also

Calcium-dependent protein kinase, a member of the CaM kinase family