Butyrylcholinesterase

Function Butyrylcholinesterase (BChE) is an enzyme widely distributed throughout the body in humans, but particularly prevalent in serum, where it occurs as a tetramer of catalytic subunits. It is distinguished from the homologous enzyme, acetylcholinesterase, by its ability to hydrolyze the non-natural substrate butyrylcholine as well as the neurotransmitter, acetylcholine. Relevance BChE biological role remains obscure, but mutations in the human BCHE gene result in prolonged post-surgical apnea due to the inability of the mutant BChEs to hydrolyse the local anaesthetic, succinylcholine. BChE finds medical use as a bioscavenger for overcoming organophosphate (OP) nerve agent and insecticide intoxication by interacting rapidly with the toxic agents.

spinqualitylabelsall models Human butyrylcholinesterase (PDB code 2pm8) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D structures of BChE3D structures of BChE

Updated on 15-November-2015

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• hBChE - Apo human
  • 2pm8, 1p0i - hBChE - human
    
  • 2xmb – hBChE (mutant)+SO4
    
  • 2xmc - hBChE (mutant)+F
    
  • 4aqd - hBChE (fully glycosylated)
• BChE+OP irreversible inhibitors, including nerve agents and insecticides
  • 3djy, 3dkk - hBChE+tabun
    
  • 2wid, 2wif - hBChE+Tabun analogue TA1
    
  • 2wsl, 2wig – hBChE+Tabun analogue TA4
    
  • 2wil, 2wij - hBChE+Tabun analogue TA5
    
  • 2wik - hBChE+Tabun analogue TA6
    
  • 1xlw - hBChE+echothiophate
    
  • 1xmd, 2xmd – hBChE (mutant)+echothiophate
    
  • 1p0q - hBChE+soman
    
  • 1xlu - hBChE+Di-Isopropyl-Phosphoro-Fluoridate (DFP)
    
  • 2xmg - hBChE (mutant)+VX
    
  • 1xlv – hBChE+ethyl dihydrogen phosphate
    
  • 2y1k, 4bbz - hBChE (mutant) + CBDP
    
  • 4b0p, 4b0o - hBChE (Aged) + pyridinium derivative
    
  • 4axb – hBChE (aged) + 2-PAM
• BChE+inhibitor binding at surface of the protein (far from the active site)
  • 2j4c – hBChE+ HgCl2
    
• BChE + substrate analogues mimicking the binding of the substrate butyrylcholine
  • 1p0m - hBChE+choline
    
  • 1p0p - hBChE+butyrylthiocholine
    
  • 3o9m - hBChE + benzoic acid
    
  • 1eho, 1ehq, 1kcj – hBChE + cocaine - model
    
  • 4bds – hBChE + tacrine
    

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