Aspartate carbamoyltransferase

Function Aspartate carbamoyltransferase (ATC) is part of the pyrimidine biosynthesis pathway. ATC catalyzes the condensation of aspartate and carbamoyl phosphate to N-carbamyl-L-aspartate and phosphate. The Zn atom is essential for the association of the subunits. Binding of the substrate to the catalytic subunits results in a high-affinity state while binding of CTP to the regulatory subunit results in a low-affinity state. Malate and phosphonoacetyl-L-aspartate (PALA) are inhibitors of ATC. For additional details see Aspartate Transcarbamoylase (ATCase). Structural highlights ATC is composed of 2 trimers of catalytic subunits (C) and 3 dimers of regulatory subunits (R). The catalytic subunit contains an aspartate-binding domain and a carbamoyl-phosphate-binding domain. The regulatory subunit contains a nucleotide effectors-binding domain and a zinc domain.

spinqualitylabelsall models Structure of E. coli aspartate carbamoyltransferase catalytic (grey and pink) and regulatory (green and yellow) subunits complex with CTP (stick figure) and Zn+2 (grey) (PDB code 1raa). Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D structures of aspartate carbamoyltransferase3D structures of aspartate carbamoyltransferase

Updated on 08-November-2015

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• ATC
  • 2atc, 3at1, 6at1, 1pg5, 3d7s, 4wto – EcATC C+R subunits – Escherichia coli
    
  • 9atc – EcATC C (mutant) + R (mutant) subunits
    
  • 1ezz, 4e2f – EcATC C (mutant) + R subunits
    
  • 2qg9, 2qgf – EcATC C + R (mutant) subunits
    
  • 3csu – EcATC C
    
  • 1gq3, 3npm – EcATC C (mutant)
    
  • 2be7 – ATC C (mutant) + R subunits – Moritella profunda
    
  • 2at2, 3r7d, 3r7f – BsATC – Bacillus subtilis
    
  • 2rgw, 3e2p, 4ekn – MjATC C subunit – Methanocaldococcus jannaschii
    
  • 3lxm – ATC C subunit – Yersinia pestis
    
• ATC binary complex
  • 1at1 – EcATC C+R subunits + malonate
    
  • 1sku – EcATC C (mutant) +R subunits + malonate
    
  • 1r0b – EcATC C+R subunits + citrate
    
  • 1r0c – EcATC C+R subunits + N-carbamoyl-L-aspartate + phosphate
    
  • 1xjw – EcATC C (mutant) +R subunits + PALA
    
  • 1sku – EcATC C (mutant) +R subunits + phosphonoacetamide
    
  • 1tu0 – EcATC C+R subunits + maltose
    
  • 4at1 – EcATC C+R subunits + ATP
    
  • 5at1, 1raa, 1rab, 1rac, 1rad, 1rae, 1raf, 1rag, 1rah, 1rai, 1za1, 4fyw – EcATC C+R subunits + CTP
    
  • 8atc, 1acm, 1d09, 1q95 – EcATC C+R subunits + PALA
    
  • 1f1b, 1i5o, 1tth – EcATC C (mutant) +R subunits + PALA
    
  • 2h3e, 2ipo – EcATC C+R subunits + phosphonacetyl asparagine
    
  • 1nbe – EcATC C (mutant) + R (mutant) subunits + malate
    
  • 2a0f – EcATC C (mutant) +R subunits + phosphonoacetamide
    
  • 3mpu – EcATC C (mutant) +R subunits + phosphate
    
  • 1ekx – EcATC C + bisubstrate analog
    
  • 1ml4 – ATC C + bisubstrate analog – Pyrococcus abyssi
    
  • 2be9 – ATC C+R subunits + CTP – Sulfolobus acidocaldarius
    
  • 2yww – MjATC R subunit + ATP
    
  • 3d6n – AaATC + dihydroorotase – Aqiufex aeolicus
    
  • 3r7l – BsATC + PALA
    
• ATC ternary complex
  • 7at1 – EcATC C+R subunits + ATP + maltose
    
  • 8at1 – EcATC C+R subunits + CTP + maltose
    
  • 4fyv – EcATC C+R subunits + dCTP + phosphate
    
  • 4fyx – EcATC C+R subunits + dCTP + UTP
    
  • 4fyy – EcATC C+R subunits + CTP + UTP
    
  • 1za2 – EcATC C+R subunits + CTP + phosphoric monoformamide ester
    
  • 2air – EcATC C+R subunits + L-alanosine + phosphoric monoformamide ester
    
  • 2fzc, 2fzg – EcATC C+R subunits + CTP + phosphonic acid derivative
    
  • 2fzk – EcATC C+R subunits + CTP + phosphonacetyl benzoate
    
  • 4f04, 4kgv, 4kgx, 4kgz, 4kh0 – EcATC C+R subunits + nucleotide + PALA
    
  • 2h3e – EcATC C+R subunits + phosphonacetyl asparagine + malate
    
  • 2at1 – EcATC C+R subunits + phosphonacetamide + malate
    
  • 2hse – EcATC C+R subunits + phosphonacetamide + aspartate
    
  • 3d6n – AaATC + dihydroorotase + PALA
    
• ATC quaternary complex
  • 1tug – EcATC C (mutant) +R subunits + phosphate + aspartate + phosphonoacetamide
    
  • 1tug – EcATC C (mutant) +R subunits + CTP + malonate + phosphonoacetamide
    
  • 4kh1 – EcATC C+R subunits + UTP + CTP + phosphate + phosphonacetyl aspartate