14-3-3 protein

Function 14-3-3 proteins (PRS) are conserved regulatory proteins which bind to a multitude of signaling proteins like kinases phosphatases and transmembrane receptors. The name 14-3-3 derives from their elution pattern via chromatography. Disease Elevated levels of PRS are found in patients with Creutzfeld-Jakob disease (CJD). PRS are associated with Parkinson Disease (PD) and with Alzheimer Disease (AD) based on their localization and their binding withPD and AD-associated proteins. Relevance PRS are tested as biomarkers for CJD, PD and AD. Structural highlights PRS are homo- and heterodimers containing 9 antiparallel α-helices. Three of the helices form the dimerization interaction and four others are involved in ligand binding.

spinqualitylabelsall models Structure of human 14-3-3 protein σ complex with Raf-1 peptide (green) and stabilizer (PDB code 3o8i). Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D structures of 14-3-3 proteins (Updated on 21-October-2015)3D structures of 14-3-3 proteins (Updated on 21-October-2015)

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• 14-3-3 protein σ
  • 1yz5 – hPRS – human
    
• 14-3-3 protein σ binary complex with peptide
  • 1ywt – hPRS + phosphopeptide
    
  • 3lw1 – hPRS + p53 peptide
    
  • 3iqj, 3iqu, 4iea – hPRS + Raf-1 peptide
    
  • 3mhr – hPRS + YAP peptide
    
  • 3p1n – hPRS + TASK-3 peptide
    
  • 3p1p, 3p1r – hPRS (mutant) + TASK-3 peptide
    
  • 4dat, 4dau – hPRS + PADI6 peptide
    
  • 4jc3, 4jdd – hPRS + estrogen receptor peptide
    
  • 4fl5 – hPRS + τ protein peptide
    
• 14-3-3 protein σ binary complex with small molecule
  • 3u9x – hPRS + pyridoxal phosphate
    
  • 3t0l, 3t0m, 4dhm, 4dhn, 4dho, 4dhp, 4dhq, 4dhr, 4dhs, 4dht, 4dhu – hPRS + inhibitor
    
  • 4hqw, 4hru – hPRS + molecular tweezers
    
• 14-3-3 protein σ ternary complex with stabilizer*
  • 3p1o, 3ux0, 4fr3 – hPRS + TASK-3 peptide + stabilizer
    
  • 3p1q, 3p1s, 3spr, 3smk, 3sml, 3smm, 3smn, 3smo – hPRS (mutant) + TASK-3 peptide + stabilizer
    
  • 3iqv, 3o8i – hPRS + Raf-1 peptide + stabilizer
    
• 14-3-3 protein ζ
  • 1a4o – bPRS - bovine
    
  • 1a37 – bPRS + Raf peptide
    
  • 1a38 – bPRS + R18 peptide
    
• 14-3-3 protein ζ/δ
  • 3rdh – hPRS
    
  • 1qja, 1qjb – hPRS + phosphopeptide
    
  • 2c1j, 2c1n – hPRS + histone H3 peptide
    
  • 2o02, 4n7g, 4n7y, 4n84 – hPRS + exoenzyme S peptide
    
  • 2v7d, 4hkc – hPRS + integrin peptide
    
  • 3cu8, 3nkx, 4fj3, 4ihl – hPRS + Raf-1 peptide
    
  • 2wh0 – hPRS + protein kinase C ε peptide
    
  • 4bg6 – hPRS + RND3 peptide
    
  • 1ib1 – hPRS + serotonin N-acetyltransferase
    
• 14-3-3 protein γ
  • 4e2e – hPRS
    
  • 2b05 – hPRS + phosphopeptide
    
  • 3uzd – hPRS + histone deacylase peptide
    
  • 4j6s – hPRS + tyrosine hydroxylase peptide
    
  • 4o46 – hPRS + influenza C-terminal peptide
    
• 14-3-3 protein β/α
  • 2bq0, 4dnk – hPRS
    
  • 2c23 – hPRS + exoenzyme S peptide
    
  • 4gnt – PRS + CHREBP peptide - mouse
    
• 14-3-3 protein θ
  • 2btp – hPRS + phosphopeptide
    
• 14-3-3 protein η
  • 2c63, 2c74 – hPRS + phosphopeptide
    
• 14-3-3 protein ε
  • 2br9 – hPRS + phosphopeptide
    
  • 3ual, 3ubw – hPRS + myeloid leukemia factor 1 peptide
    
• 14-3-3 protein
  • 3efz – PRS + phosphoserine – Cryptosporidium parvum
    
  • 4f7r – PRS – Giardia intestinalis