Thrombin heavy chain

<StructureSection load='3vxe' size='340' side='right' caption='The best structure for Thrombin heavy chain shown: 3vxe' scene=> Best example is PDB entry 3vxe and is shown in the viewer.
Molecule Thrombin heavy chain, also known as Thrombin light chain, Activation peptide fragment 2, Coagulation factor II, Prothrombin, Thrombin heavy chain and Activation peptide fragment 1.

FunctionFunction

Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing.Data source: Uniprot P00734

Catalytic ActivityCatalytic Activity

Selective cleavage of Arg-|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B.Data source: Uniprot P00734

Biological processBiological process

Is involved in the following biological processes:
proteolysis
blood coagulation
cellular protein metabolic process
hemostasis
multicellular organismal development
leukocyte migration
cellular response to mechanical stimulus
regulation of gene expression
response to inactivity
negative regulation of platelet activation
cytosolic calcium ion homeostasis
response to wounding
positive regulation of cell proliferation
platelet activation
acute-phase response
negative regulation of proteolysis
cell surface receptor signaling pathway
positive regulation of release of sequestered calcium ion into cytosol
negative regulation of astrocyte differentiation
blood coagulation, intrinsic pathway
regulation of cell shape
positive regulation of protein phosphorylation
post-translational protein modification
positive regulation of cell growth
positive regulation of reactive oxygen species metabolic process
positive regulation of phosphatidylinositol 3-kinase signaling
regulation of blood coagulation
positive regulation of blood coagulation
fibrinolysis
peptidyl-glutamic acid carboxylation
positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway
negative regulation of fibrinolysis
positive regulation of collagen biosynthetic process

In structuresIn structures

Thrombin heavy chain is found in 397 PDB entries

• Eukaryota (397 PDB entries):
  
  • Homo sapiens (362 PDB entries):
    
    • 3vxe
    • Title: Human alpha-thrombin-Bivalirudin complex at PD5.0
    • 1.25 A resolution
    • Other macromolecules also in this entry: Thrombin light chain, BIVALIRUDIN, Hirudin-2.
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  • Bos taurus (28 PDB entries):
    
    • 2ody
    • Title: Thrombin-bound boophilin displays a functional and accessible reactive-site loop
    • 2.35 A resolution
    • Other macromolecules also in this entry: Thrombin light chain, Boophilin-H2, .
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  • Mus musculus (7 PDB entries):
    
    • 3hk3
    • Title: Crystal structure of murine thrombin mutant W215A/E217A (one molecule in the asymmetric unit)
    • 1.94 A resolution
    • Other macromolecules also in this entry: Thrombin light chain..
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