2pd6

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Structure of human hydroxysteroid dehydrogenase type 8, HSD17B8Structure of human hydroxysteroid dehydrogenase type 8, HSD17B8

Structural highlights

2pd6 is a 4 chain structure with sequence from Human. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:
Gene:HSD17B8, FABGL, HKE6, RING2 (HUMAN)
Activity:17-beta-estradiol 17-dehydrogenase, with EC number 1.1.1.62
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum

Function

[DHB8_HUMAN] NAD-dependent 17-beta-hydroxysteroid dehydrogenase with highest activity towards estradiol. Has very low activity towards testosterone. The heteroteramer with CBR4 has NADH-dependent 3-ketoacyl-acyl carrier protein reductase activity. May play a role in biosynthesis of fatty acids in mitochondria.[1] [2]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

References

  1. ↑ Ohno S, Nishikawa K, Honda Y, Nakajin S. Expression in E. coli and tissue distribution of the human homologue of the mouse Ke 6 gene, 17beta-hydroxysteroid dehydrogenase type 8. Mol Cell Biochem. 2008 Feb;309(1-2):209-15. Epub 2007 Nov 3. PMID:17978863 doi:http://dx.doi.org/10.1007/s11010-007-9637-9
  2. ↑ Chen Z, Kastaniotis AJ, Miinalainen IJ, Rajaram V, Wierenga RK, Hiltunen JK. 17beta-hydroxysteroid dehydrogenase type 8 and carbonyl reductase type 4 assemble as a ketoacyl reductase of human mitochondrial FAS. FASEB J. 2009 Nov;23(11):3682-91. Epub 2009 Jul 1. PMID:19571038 doi:http://dx.doi.org/fj.09-133587

2pd6, resolution 2.00Å

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