1pdu
Ligand-binding domain of Drosophila orphan nuclear receptor DHR38Ligand-binding domain of Drosophila orphan nuclear receptor DHR38
Structural highlights
Function[HR38_DROME] Binds to NGFI-B response elements. Plays an important role in late stages of epidermal metamorphosis. Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMedEcdysteroid pulses trigger the major developmental transitions during the Drosophila life cycle. These hormonal responses are thought to be mediated by the ecdysteroid receptor (EcR) and its heterodimeric partner Ultraspiracle (USP). We provide evidence for a second ecdysteroid signaling pathway mediated by DHR38, the Drosophila ortholog of the mammalian NGFI-B subfamily of orphan nuclear receptors. DHR38 also heterodimerizes with USP, and this complex responds to a distinct class of ecdysteroids in a manner that is independent of EcR. This response is unusual in that it does not involve direct binding of ecdysteroids to either DHR38 or USP. X-ray crystallographic analysis of DHR38 reveals the absence of both a classic ligand binding pocket and coactivator binding site, features that seem to be common to all NGFI-B subfamily members. Taken together, these data reveal the existence of a separate structural class of nuclear receptors that is conserved from fly to humans. The Drosophila orphan nuclear receptor DHR38 mediates an atypical ecdysteroid signaling pathway.,Baker KD, Shewchuk LM, Kozlova T, Makishima M, Hassell A, Wisely B, Caravella JA, Lambert MH, Reinking JL, Krause H, Thummel CS, Willson TM, Mangelsdorf DJ Cell. 2003 Jun 13;113(6):731-42. PMID:12809604[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. References
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