2ic5
Crystal structure of human RAC3 grown in the presence of Gpp(NH)p.Crystal structure of human RAC3 grown in the presence of Gpp(NH)p.
Structural highlights
Function[RAC3_HUMAN] Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as cell spreading and the formation of actin-based protusions including lamellipodia and membrane ruffles.[1] Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. References |
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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)
OCACategories:
- Human
- Arrowsmith, C
- Bunkoczi, G
- Burgess, N
- Colebrook, S
- Delft, F von
- Doyle, D
- Edwards, A
- Elkins, J
- Fedorov, O
- Gileadi, C
- Gileadi, O
- Structural genomic
- Sundstrom, M
- Ugochukwu, E
- Weigelt, J
- Yang, X
- Zao, Y
- Gppnhp
- Gtpase rac3
- P21 rac
- Ras-related c3 botulinum toxin substrate 3
- Sgc
- Signaling protein
- Signalling protein
- Small gtp binding protein