Receptor for activated protein kinase C 1

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Receptor for activated protein kinase C 1 (RACK1) is a scaffold protein which is able to interact simultaneously with several signaling molecules. It binds to protein kinases and to membrane-bound receptors. RACK1 is also part of the eukaryotic ribosome and it localizes to the small 40S subunit. RACK1 recruits activated protein kinase to the ribosome and allows translation to be linked to cellular stimuli.

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Structural highlights

Human receptor for activated protein kinase C 1 (PDB code 4aow)

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3D Structures of receptor for activated protein kinase C 13D Structures of receptor for activated protein kinase C 1

Updated on 23-July-2015

3frx, 3rfg, 3rfh – yRACK1 – yeast
4aow – hRACK1 – human
1trj – yRACK1 + RNA – Cryo EM
3j6x, 3j6y, 4v6i, 4v7r, 3j77, 3j78, 4u3m, 4u3n, 4u3u, 4u4n, 4u4o, 4u4r, 4u4u, 4u4y, 4u4z, 4u50, 4u51, 4u52, 4u53, 4u55, 4u56, 4u6f – yRACK1 in y80S ribosome – Cryo EM
4v6x, 5aj0, 4ug0, 5a2q – hRACK1 in h80S ribosome – Cryo EM <br

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Michal Harel