4pl6

Structure of the chromodomain of MRG2 in complex with H3K4me3Structure of the chromodomain of MRG2 in complex with H3K4me3

Structural highlights

4pl6 is a 4 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
NonStd Res:
Related:	4pli, 4pll
Resources:	FirstGlance, OCA, RCSB, PDBsum

Function

[MRG2_ARATH] Chromatin remodeling factor. Acts as a 'reader' protein by binding to H3K4me3 and H3K36me3 to control histone H4 acetylation. Increases the transcriptional levels of the flowering time genes FLC and FT (PubMed:25183522, PubMed:25211338). Binds the chromatin at the FT promoter upon interaction with CO (PubMed:25211338).^[1] ^[2]

References

↑ Xu Y, Gan ES, Zhou J, Wee WY, Zhang X, Ito T. Arabidopsis MRG domain proteins bridge two histone modifications to elevate expression of flowering genes. Nucleic Acids Res. 2014;42(17):10960-74. doi: 10.1093/nar/gku781. Epub 2014 Sep, 2. PMID:25183522 doi:http://dx.doi.org/10.1093/nar/gku781
↑ Bu Z, Yu Y, Li Z, Liu Y, Jiang W, Huang Y, Dong AW. Regulation of arabidopsis flowering by the histone mark readers MRG1/2 via interaction with CONSTANS to modulate FT expression. PLoS Genet. 2014 Sep 11;10(9):e1004617. doi: 10.1371/journal.pgen.1004617., eCollection 2014 Sep. PMID:25211338 doi:http://dx.doi.org/10.1371/journal.pgen.1004617

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OCA

[1] Xu Y, Gan ES, Zhou J, Wee WY, Zhang X, Ito T. Arabidopsis MRG domain proteins bridge two histone modifications to elevate expression of flowering genes. Nucleic Acids Res. 2014;42(17):10960-74. doi: 10.1093/nar/gku781. Epub 2014 Sep, 2. PMID:25183522 doi:http://dx.doi.org/10.1093/nar/gku781

[2] Bu Z, Yu Y, Li Z, Liu Y, Jiang W, Huang Y, Dong AW. Regulation of arabidopsis flowering by the histone mark readers MRG1/2 via interaction with CONSTANS to modulate FT expression. PLoS Genet. 2014 Sep 11;10(9):e1004617. doi: 10.1371/journal.pgen.1004617., eCollection 2014 Sep. PMID:25211338 doi:http://dx.doi.org/10.1371/journal.pgen.1004617

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[2]

4pl6

Structure of the chromodomain of MRG2 in complex with H3K4me3Structure of the chromodomain of MRG2 in complex with H3K4me3

Structural highlights

Function

References

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4pl6

Structure of the chromodomain of MRG2 in complex with H3K4me3Structure of the chromodomain of MRG2 in complex with H3K4me3

Structural highlights

Function

References

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