Ribosome inactivating protein

Ribosome inactivating protein (RIP) is a bacterial or plant toxin which inhibits protein synthesis. RIP inactivates the ribosomal 60S subunit by N-glycosidic cleavage which results in releasing a specific adenine from 28S rRNA. Type 1 RIP has a single chain, while type 2 RIP has two chains. Enhanced expression of RIP in plants confers an increased resistance to virus, fungi, insects, drought and salinity. Relevance RIP is being investigated as an immunotoxin for cancer treatment. Besides the anti-tumor activity of RIP, it was shown to have antiviral, antifungal, insecticidal, ribonuclease and deoxyribonuclease activities.

spinqualitylabelsall models Glycosylated type 1 ribosome inactivating protein from bitter gourd complex with adenine and glycerol (PDB code 3u70) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D Structures of ribosome inactivating protein3D Structures of ribosome inactivating protein

Updated on 08-July-2015

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• Pokeweed ribosome inactivating protein
  • 1apa, 1paf, 1pag, 1qcg – apRIP – american pokeweed
    
  • 1j1q, 1gik – apRIP-S
    
  • 1j1r – apRIP-S + adenine
    
  • 1j1s – apRIP-S + formycin
    
  • 1qci – apRIP + adenine
    
  • 1d6a – apRIP + guanine
    
  • 1qcj – apRIP + pteoric acid
    
  • 1lln – apRIP-3 + methylated lysine
    
• Dianthin 30 ribosome inactivating protein
  • 1lp8, 1rl0 – cpRIP – clove pink
    
  • 1lpc – cpRIP + cAMP
    
  • 1lpd – cpRIP + adenine
    
• Type 1 ribosome inactivating protein
  • 2g5x – RIP – scarlet lychnis
    
  • 3ctk – RIP – bougainvillea
    
  • 3mrw, 3s9q, 4kmk, 4kwn, 4l66 – bgRIP – bitter gourd
    
• Type 1 ribosome inactivating protein complex with nucleotide
  • 3mry – bgRIP + aminopurine
    
  • 4kpv – bgRIP + pyrimidine derivative
    
  • 3rl9, 3u6z, 3u70, 3v2k – bgRIP + adenine
    
  • 4dwm, 4rzj – bgRIP + NAG
    
  • 3n1n – baRIP + guanine – balsam apple
    
  • 4f9n, 4i47 – bgRIP + guanine
    
  • 4fpz, 4o0o – bgRIP + uracil derivative
    
  • 4g2x, 4k6p, 4ztw – bgRIP + cytidine
    
  • 4kjh, 4zt8 – bgRIP + cytosine
    
  • 4k6q, 4zu0 – bgRIP + CMP
    
  • 4qgj, 4z44 – bgRIP + CDP
    
  • 4k6s, 4zz6 – bgRIP + CTP
    
  • 4o4q – bgRIP + UDP
    
  • 4o8e – bgRIP + UTP
    
  • 4q9f – bgRIP + GMP
    
  • 3q4p, 3qji, 4emf, 4emr – bgRIP + guanosine derivative
    
• Type 1 ribosome inactivating protein complex with peptide
  • 4fxa, 4lt4, 4m5a – bgRIP + arginine derivative
    
  • 3n3x – baRIP + polypeptide
    
  • 3n2d – bgRIP + polypeptide
    
• Type 1 ribosome inactivating protein other complexes
  • 3n31, 3n5d, 3n31, 3nfm, 3njs, 3nx9, 3n1d – baRIP + sugar
    
  • 3v14, 4fz9, 4guw, 4hoa – bgRIP + sugar
    
  • 4lro – bgRIP + spermidine
    
  • 3sj6 – bgRIP + oxalane derivative
    
  • 3u6t – bgRIP + kanamycin
    
  • 3u8f – bgRIP + mycolic acid
    
  • 4h0z – bgRIP + acetyl-muramic acid
    
  • 4jtp – bgRIP + ascorbic acid
    
  • 4k2z – bgRIP + methylethylamine
    
  • 4kl4 – bgRIP + PEG
    
  • 4jtb – bgRIP + phosphate
    
  • 4lwx – bgRIP + peptidoglycan