Prolactin

Function

Prolactin (PRL) is a hormone which has numerous effects. It enables females to produce milk. PRL provides the body with sexual gratification. PRL promotes neurogenesis in maternal and fetal brains. PRL stimulates cells which are responsible for the formation of myelin coating on axons. See also Prolactin (Hebrew).

Disease

Relevance

Structural highlights

Human prolactin (grey) complex with prolactin receptor extracellular domain (green), Na+ (purple) and Ca+2 (green) ions (PDB code 3mzg).

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3D Structures of prolactinin3D Structures of prolactinin

Updated on 20-May-2015

1rw5 – hPRL – human - NMR
2q98 – hPRL (mutant)
3mzg, 3npz – hPRL + hPRL receptor extracellular domain
3d48, 3n06, 3n0p, 3ncb – hPRL (mutant) + hPRL receptor extracellular domain
3ncc, 3nce, 3ncf – hPRL (mutant) + hPRL receptor extracellular domain (mutant)
3ew3 – hPRL + rPRL receptor extracellular domain - rat
4i18 - hPRL receptor extracellular domain + antibody

ReferencesReferences

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Michal Harel