Phosphoenolpyruvate carboxykinase

Phosphoenolpyruvate carboxykinase (PEPCK) catalyzes the conversion of oxaloacetate to phosphoenolpyruvate (PEP) and CO2. PEPCK is part of the gluconeogenesis pathway. There are 3 types of PEPCK distinguished by the energy source of the reaction which can be GTP, ATP or diphosphate.

3D Structures of PEPCK3D Structures of PEPCK

Updated on 12-May-2015

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• Phosphoenolpyruvate carboxykinase ATP driven
  • 1oen, 1fiy – EcPEPCK - Escherichia coli
    
  • 1ayl – EcPEPCK + ATP + oxalate + Mg
    
  • 1aq2 – EcPEPCK + ATP + pyruvate + Mg + Mn
    
  • 2py7 – EcPEPCK (mutant) + ATP + Mg + Mn
    
  • 2olq – EcPEPCK + ATP + CO2 + Mg + Mn
    
  • 2pxz – EcPEPCK + ATP + CO2 + oxaloacetate + Mg + Mn
    
  • 2olr – EcPEPCK + ATP + CO2 + Mg
    
  • 1os1 – EcPEPCK + ATP + pyruvate + Mg + Ca
    
  • 1k3c – EcPEPCK + ADP + pyruvate + Mg + AlF3
    
  • 1k3d – EcPEPCK + ADP + Mg + AlF3
    
  • 1j3b – TtPEPCK – Thermus thermophilus
    
  • 1yvy – AnsPEPCK – Anaerobiospirillum succiniciproducens
    
  • 1ytm – AnsPEPCK + ATP + oxalate + Mg + Mn
    
  • 1xkv, 2pc9 – TtPEPCK + ATP
    
• Phosphoenolpyruvate carboxykinase GTP driven
  • 1khf – EcPEPCK + PEP + Mn
    
  • 1khg – EcPEPCK + Mn
    
  • 1m51, 1nhx – EcPEPCK + inhibitor + Mn
    
  • 2faf – cPEPCK + Mn - chicken
    
  • 2qzy – cPEPCK + PEP + Mn
    
  • 2gmv – hPEPCK + inhibitor + PEP + Mn - human
    
  • 2qew – rPEPCK + Mn - rat
    
  • 2qf1 – rPEPCK + oxaloacetate + Mn
    
  • 2rk7 – rPEPCK + oxalate + Mn
    
  • 2rk8, 2rka, 2rkd, 2rke – rPEPCK + inhibitor + Mn
    
  • 4wiu – MtPEPCK + oxalate + Mn – Mycobacterium tuberculosis
    
  • 4wie – MtPEPCK + Mn
    
• PEPCK GTP driven complex with nucleotide
  • 1khb – EcPEPCK + GTP analog + Mg
    
  • 1khe – EcPEPCK + GTP analog + Mn
    
  • 2fah – cPEPCK + GDP + Mn
    
  • 2qey – rPEPCK + GTP + Mn
    
  • 4gnm, 4gnq - rPEPCK + oxalate + GTP + Mn
    
  • 4gmw, 4gnl, 4gnp – rPEPCK + PEP + GDP + Mn
    
  • 3dt2, 3dt4, 4gmu – rPEPCK + GTP + oxalate + Mn
    
  • 3mof – rPEPCK (mutant) + GTP + oxalate + Mn
    
  • 3dt7, 4gmm, 4gmz, 4gno – rPEPCK + GTP + sulfopyruvate + Mn
    
  • 3moe, 4ox2 – rPEPCK (mutant) + GTP + sulfopyruvate + Mn
    
  • 3dtb – rPEPCK + GTP + phosphoglycolate + Mn
    
  • 3moh – rPEPCK (mutant) + GDP + phosphoglycolate + Mn
    
  • 2qf2 – rPEPCK + GDP + oxaloacetate + Mn
    
  • 4rcg – MtPEPCK + GDP + Mg
    
  • 4r43 – MtPEPCK + GDP + Mn
    
• PEPCK
  • 2zci – PEPCK – Corynebacterium glutamicum
    
  • 1ygg – AsPEPCK – Actinobacillus succinogenes
    
  • 1ylh – AsPEPCK + pyruvate + Mn
    
  • 1ii2 – PEPCK – Trypanosoma cruzi