Macrophage inhibitory factor

Macrophage inhibitory factor (MIF) is an inflammatory cytokine. MIF is released to the blood stream upon stimulation of white blood cells by bacterial antigens. MIF contains two different catalytic sites. A phenylpyruvate tautomerase site is located in the N terminal. A disulfide reductase site is located in the tetrapeptide Cys-Ala-Leu-Cys in position 57-60.

spinqualitylabelsall models Structure of human macrophage inhibitory factor trimer complex with inhibitor, glycerol and sulfate (PDB entry 2ooh) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D structures of macrophage inhibitory factor3D structures of macrophage inhibitory factor

Updated on 04-May-2015

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• macrophage inhibitory factor
  • 1mif – MIF (mutant) – rat
    
  • 1fim, 1gif, 1gd0, 3djh – hMIF – human
    
  • 1cgq, 1p1g, 4etg, 4eui, 4evg, 4grn, 4gro, 4grp, 4grq, 4grr, 4gru – hMIF (mutant)
    
  • 1mff – mMIF (mutant) – mouse
    
  • 1hfo – MIF – Trichinella spiralis
    
  • 1uiz – MIF – Xenopus laevis
    
  • 2wkb, 2wkf – MIF – Plasmodium berghei
    
  • 3t5s – MIF – Giardia lamblia
    
  • 4gum – MIF (mutant) – rhesus monkey
    
  • 4dh4 – MIF – Toxoplasma gondii
    
• MIF complexes
  • 1mfi, 2gdg – mMIF + inhibitor
    
  • 1ca7 – hMIF + hydroxyphenylpyruvate
    
  • 3ijj – hMIF + hydroxyphenylpyruvate + inhibitor
    
  • 1gcz, 1ljt, 2ooh, 2oow, 2ooz, 3b9s, 3jsf, 3jsg, 3jtu, 3l5p, 3l5r, 3l5s, 3l5t, 3l5u, 3l5v, 3ijg, 4f2k, 3smb, 3smc, 3wnr, 3wns, 3wnt, 4osf, 4p01, 4k9g, 4oyq, 4p0h, 4wr8, 4wrb – hMIF + inhibitor
    
  • 3dji – hMIF + tylenol
    
  • 3ce4 – hMIF + PMSF
    
  • 3hof – hMIF + cafeic acid
    
  • 3u18 – hMIF + Chicago sky blue
    
  • 3rf4, 3rf5 – MIF + inhibitor – Ancylostoma ceylanicum
    
  • 4p7m, 4p7s – MIF + inhibitor – Plasmodium falciparum