4xui

Crystal structure analysis of cruzain bound to the no-covalent analog of WRR-483 (WRR-669)Crystal structure analysis of cruzain bound to the no-covalent analog of WRR-483 (WRR-669)

Structural highlights

4xui is a 3 chain structure. This structure supersedes the now removed PDB entry 4pi4. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:	,
Related:	4pi3
Activity:	Cruzipain, with EC number 3.4.22.51
Resources:	FirstGlance, OCA, RCSB, PDBsum

Function

[CYSP_TRYCR] Hydrolyzes chromogenic peptides at the carboxyl Arg or Lys; requires at least one more amino acid, preferably Arg, Phe, Val or Leu, between the terminal Arg or Lys and the amino-blocking group. The cysteine protease may play an important role in the development and differentiation of the parasites at several stages of their life cycle.

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OCA