Beta-lactoglobulin

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Revision as of 12:30, 8 March 2015 by Michal Harel (talk | contribs)
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β-lactoglobulin is a CBI Molecules being studied in the University of Massachusetts Amherst Chemistry-Biology Interface Program at UMass Amherst and on display at the Molecular Playground.

BLG as studied in the Dubin Lab

β-lactoglobulin is a dimeric protein that exists in two forms. BLG A and BLG B, which differ by two mutations, one of which is a non-charged residue being replaced by an Aspartic Acid, which at relevant pH values is negatively charged. The result is a protein that exists in two isoforms, which differ by two negative charges (one per monomer).

The differences between these two forms significantly augment the electrostatic potential, making BLG A & BLG B an ideal system for studying the interaction of a protein with a polyelectrolyte. More details in Molecular Playground/BLG.

Bovine β-lactoglobulin (PDB code 1beb)

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3D structures of beta-lactoglobulin3D structures of beta-lactoglobulin

Updated on 08-March-2015

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky