4ue9

Complex OF D. melanogaster EIF4E with the 4E binding protein 4E-TComplex OF D. melanogaster EIF4E with the 4E binding protein 4E-T

Structural highlights

4ue9 is a 2 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Related:	4ue8, 4uea, 4ueb, 4uec, 4ued
Resources:	FirstGlance, OCA, RCSB, PDBsum

Function

[IF4E_DROME] Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures.^[1]

References

↑ Lavoie CA, Lachance PE, Sonenberg N, Lasko P. Alternatively spliced transcripts from the Drosophila eIF4E gene produce two different Cap-binding proteins. J Biol Chem. 1996 Jul 5;271(27):16393-8. PMID:8663200

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OCA

[1] Lavoie CA, Lachance PE, Sonenberg N, Lasko P. Alternatively spliced transcripts from the Drosophila eIF4E gene produce two different Cap-binding proteins. J Biol Chem. 1996 Jul 5;271(27):16393-8. PMID:8663200

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