2ypr

Crystal structure of the DNA binding ETS domain of human protein FEVCrystal structure of the DNA binding ETS domain of human protein FEV

Structural highlights

2ypr is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:
Resources:	FirstGlance, OCA, RCSB, PDBsum

Disease

[FEV_HUMAN] Disease susceptibility may be associated with variations affecting the gene represented in this entry. A chromosomal aberration involving FEV is found in Ewing tumors. Translocation t(2;21;22)(q23;q22;q12) that forms a EWSR1-FEV fusion protein with a potential oncogenic activity.

Function

[FEV_HUMAN] Functions as a transcriptional regulator. According to PubMed:12761502, it functions as a transcriptional repressor. Functions in the differentiation and the maintenance of the central serotonergic neurons. May play a role in cell growth.^[1]

References

↑ Maurer P, T'Sas F, Coutte L, Callens N, Brenner C, Van Lint C, de Launoit Y, Baert JL. FEV acts as a transcriptional repressor through its DNA-binding ETS domain and alanine-rich domain. Oncogene. 2003 May 22;22(21):3319-29. PMID:12761502 doi:http://dx.doi.org/10.1038/sj.onc.1206572

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

[1] Maurer P, T'Sas F, Coutte L, Callens N, Brenner C, Van Lint C, de Launoit Y, Baert JL. FEV acts as a transcriptional repressor through its DNA-binding ETS domain and alanine-rich domain. Oncogene. 2003 May 22;22(21):3319-29. PMID:12761502 doi:http://dx.doi.org/10.1038/sj.onc.1206572

[1]