2hck
SRC FAMILY KINASE HCK-QUERCETIN COMPLEX
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| , resolution 3.0Å | |||||||
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| Ligands: | and | ||||||
| Gene: | HUMAN HCK (Homo sapiens) | ||||||
| Activity: | Transferase, with EC number and 2.7.10.2 2.7.10.1 and 2.7.10.2 | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
OverviewOverview
The crystal structure of the haematopoietic cell kinase Hck has been determined at 2.6/2.9 A resolution. Inhibition of enzymatic activity is a consequence of intramolecular interactions of the enzyme's Src-homology domains SH2 and SH3, with concomitant displacement of elements of the catalytic domain. The conformation of the active site has similarities with that of inactive cyclin-dependent protein kinases.
About this StructureAbout this Structure
2HCK is a Single protein structure of sequence from Homo sapiens. The following page contains interesting information on the relation of 2HCK with [Src Tyrosine Kinase]. Full crystallographic information is available from OCA.
ReferenceReference
Crystal structure of the Src family tyrosine kinase Hck., Sicheri F, Moarefi I, Kuriyan J, Nature. 1997 Feb 13;385(6617):602-9. PMID:9024658
Page seeded by OCA on Thu Mar 20 17:15:22 2008