3sqf

Crystal structure of monomeric M-PMV retroviral proteaseCrystal structure of monomeric M-PMV retroviral protease

Structural highlights

3sqf is a 2 chain structure with sequence from Mpmv. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Related:	1nso, 3hvp, 4hvp, 2rsp, 1yth, 4fiv, 2fmb, 3liy, 3nr6
Gene:	pro, prt (MPMV)
Resources:	FirstGlance, OCA, RCSB, PDBsum

Publication Abstract from PubMed

Following the failure of a wide range of attempts to solve the crystal structure of M-PMV retroviral protease by molecular replacement, we challenged players of the protein folding game Foldit to produce accurate models of the protein. Remarkably, Foldit players were able to generate models of sufficient quality for successful molecular replacement and subsequent structure determination. The refined structure provides new insights for the design of antiretroviral drugs.

Crystal structure of a monomeric retroviral protease solved by protein folding game players.,Khatib F, Dimaio F, Cooper S, Kazmierczyk M, Gilski M, Krzywda S, Zabranska H, Pichova I, Thompson J, Popovic Z, Jaskolski M, Baker D Nat Struct Mol Biol. 2011 Sep 18. doi: 10.1038/nsmb.2119. PMID:21926992^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Khatib F, Dimaio F, Cooper S, Kazmierczyk M, Gilski M, Krzywda S, Zabranska H, Pichova I, Thompson J, Popovic Z, Jaskolski M, Baker D. Crystal structure of a monomeric retroviral protease solved by protein folding game players. Nat Struct Mol Biol. 2011 Sep 18. doi: 10.1038/nsmb.2119. PMID:21926992 doi:10.1038/nsmb.2119

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OCA

[1] Khatib F, Dimaio F, Cooper S, Kazmierczyk M, Gilski M, Krzywda S, Zabranska H, Pichova I, Thompson J, Popovic Z, Jaskolski M, Baker D. Crystal structure of a monomeric retroviral protease solved by protein folding game players. Nat Struct Mol Biol. 2011 Sep 18. doi: 10.1038/nsmb.2119. PMID:21926992 doi:10.1038/nsmb.2119

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