5'-R(*CP*GP*CP*CP*AP*GP*CP*G)-3'5'-R(*CP*GP*CP*CP*AP*GP*CP*G)-3'

Structural highlights

402d is a 2 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Resources:FirstGlance, OCA, RCSB, PDBsum

Publication Abstract from PubMed

The crystal structure of the RNA octamer 5'-CGC(CA)GCG-3' has been determined from X-ray diffraction data to 2.3 A resolution. In the crystal, this oligomer forms a self-complementary double helix in the asymmetric unit. Tandem non-Watson-Crick C-A and A-C base pairs comprise an internal loop in the middle of the duplex, which is incorporated with little distortion of the A-form double helix. From the geometry of the C-A base pairs, it is inferred that the adenosine imino group is protonated and donates a hydrogen bond to the carbonyl group of the cytosine. The wobble geometry of the C-A+ base pairs is very similar to that of the common U-G non-Watson-Crick pair.

Structure of an RNA internal loop consisting of tandem C-A+ base pairs.,Jang SB, Hung LW, Chi YI, Holbrook EL, Carter RJ, Holbrook SR Biochemistry. 1998 Aug 25;37(34):11726-31. PMID:9718295[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

  1. Jang SB, Hung LW, Chi YI, Holbrook EL, Carter RJ, Holbrook SR. Structure of an RNA internal loop consisting of tandem C-A+ base pairs. Biochemistry. 1998 Aug 25;37(34):11726-31. PMID:9718295 doi:10.1021/bi980758j

402d, resolution 2.30Å

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