2gic
Crystal Structure of a vesicular stomatitis virus nucleocapsid-RNA complex
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| , resolution 2.920Å | |||||||
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| Ligands: | |||||||
| Gene: | N (Vesicular stomatitis Indiana virus) | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
OverviewOverview
Vesicular stomatitis virus is a negative-stranded RNA virus. Its nucleoprotein (N) binds the viral genomic RNA and is involved in multiple functions including transcription, replication, and assembly. We have determined a 2.9 angstrom structure of a complex containing 10 molecules of the N protein and 90 bases of RNA. The RNA is tightly sequestered in a cavity at the interface between two lobes of the N protein. This serves to protect the RNA in the absence of polynucleotide synthesis. For the RNA to be accessed, some conformational change in the N protein should be necessary.
About this StructureAbout this Structure
2GIC is a Single protein structure of sequence from Vesicular stomatitis indiana virus. Full crystallographic information is available from OCA.
ReferenceReference
Structure of the vesicular stomatitis virus nucleoprotein-RNA complex., Green TJ, Zhang X, Wertz GW, Luo M, Science. 2006 Jul 21;313(5785):357-60. Epub 2006 Jun 15. PMID:16778022
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