4v2a

human Unc5A ectodomainhuman Unc5A ectodomain

Structural highlights 4v2a is a 1 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: Related: 4v2b, 4v2c, 4v2d, 4v2e Resources: FirstGlance, OCA, RCSB, PDBsum Function [UNC5A_HUMAN] Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand.

spinqualitylabelsall models 4v2a, resolution 2.40Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image