4lqq

Crystal structure of the Cbk1(T743E)-Mob2 kinase-coactivator complex in crystal form BCrystal structure of the Cbk1(T743E)-Mob2 kinase-coactivator complex in crystal form B

Structural highlights

4lqq is a 4 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:
Related:	4lqp, 4lqs
Activity:	Non-specific serine/threonine protein kinase, with EC number 2.7.11.1
Resources:	FirstGlance, OCA, RCSB, PDBsum

Function

[CBK1_YEAST] Protein kinase that seems to play a role in the regulation of cell morphogenesis and proliferation. [MOB2_YEAST] Functions as an activator subunit for the CBK1 protein kinase. Part of the regulation of ACE2 activity and cellular morphogenesis (RAM) signaling network. Required for coordinating polarized cell growth during interphase with the onset of mitosis. Required for mother/daughter cell separation after cytokinesis. Also has a role in the prevention of nuclear export of ACE2 from the daughter cell nucleus after mitotic exit. It coordinates ACE2-dependent transcription with mitotic exit network activation.^[1] ^[2]

References

↑ Colman-Lerner A, Chin TE, Brent R. Yeast Cbk1 and Mob2 activate daughter-specific genetic programs to induce asymmetric cell fates. Cell. 2001 Dec 14;107(6):739-50. PMID:11747810
↑ Weiss EL, Kurischko C, Zhang C, Shokat K, Drubin DG, Luca FC. The Saccharomyces cerevisiae Mob2p-Cbk1p kinase complex promotes polarized growth and acts with the mitotic exit network to facilitate daughter cell-specific localization of Ace2p transcription factor. J Cell Biol. 2002 Sep 2;158(5):885-900. Epub 2002 Aug 26. PMID:12196508 doi:http://dx.doi.org/10.1083/jcb.200203094

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OCA

[1] Colman-Lerner A, Chin TE, Brent R. Yeast Cbk1 and Mob2 activate daughter-specific genetic programs to induce asymmetric cell fates. Cell. 2001 Dec 14;107(6):739-50. PMID:11747810

[2] Weiss EL, Kurischko C, Zhang C, Shokat K, Drubin DG, Luca FC. The Saccharomyces cerevisiae Mob2p-Cbk1p kinase complex promotes polarized growth and acts with the mitotic exit network to facilitate daughter cell-specific localization of Ace2p transcription factor. J Cell Biol. 2002 Sep 2;158(5):885-900. Epub 2002 Aug 26. PMID:12196508 doi:http://dx.doi.org/10.1083/jcb.200203094

[1]

[2]

4lqq

Crystal structure of the Cbk1(T743E)-Mob2 kinase-coactivator complex in crystal form BCrystal structure of the Cbk1(T743E)-Mob2 kinase-coactivator complex in crystal form B

Structural highlights

Function

References

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4lqq

Crystal structure of the Cbk1(T743E)-Mob2 kinase-coactivator complex in crystal form BCrystal structure of the Cbk1(T743E)-Mob2 kinase-coactivator complex in crystal form B

Structural highlights

Function

References

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