3o63

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Crystal Structure of Thiamin Phosphate Synthase from Mycobacterium tuberculosisCrystal Structure of Thiamin Phosphate Synthase from Mycobacterium tuberculosis

Structural highlights

3o63 is a 2 chain structure with sequence from Mycobacterium tuberculosis. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:
Gene:MT0427, MTCY22G10.11c, Rv0414c, thiE (Mycobacterium tuberculosis)
Activity:Thiamine-phosphate diphosphorylase, with EC number 2.5.1.3
Resources:FirstGlance, OCA, RCSB, PDBsum

Function

[THIE_MYCTU] Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).[1]

References

  1. ↑ Khare G, Kar R, Tyagi AK. Identification of inhibitors against Mycobacterium tuberculosis thiamin phosphate synthase, an important target for the development of anti-TB drugs. PLoS One. 2011;6(7):e22441. doi: 10.1371/journal.pone.0022441. Epub 2011 Jul 26. PMID:21818324 doi:http://dx.doi.org/10.1371/journal.pone.0022441

3o63, resolution 2.35Å

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