4qkf

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Crystal structure of human ALKBH7 in complex with N-oxalylglycine and Mn(II)Crystal structure of human ALKBH7 in complex with N-oxalylglycine and Mn(II)

Structural highlights

4qkf is a 3 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:,
Resources:FirstGlance, OCA, RCSB, PDBsum

Function

[ALKB7_HUMAN] Probable dioxygenase required to induce programmed necrosis in response to DNA damage caused by cytotoxic alkylating agents. Acts by triggering the collapse of mitochondrial membrane potential and loss of mitochondrial function that leads to energy depletion and cell death. ALKBH7-mediated necrosis is probably required to prevent the accumulation of cells with DNA damage. Does not display DNA demethylase activity. Involved in fatty acid metabolism.[1]

References

  1. ↑ Fu D, Jordan JJ, Samson LD. Human ALKBH7 is required for alkylation and oxidation-induced programmed necrosis. Genes Dev. 2013 May 15;27(10):1089-100. doi: 10.1101/gad.215533.113. Epub 2013, May 10. PMID:23666923 doi:http://dx.doi.org/10.1101/gad.215533.113

4qkf, resolution 1.99Å

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