3pyb

Crystal structure of ent-copalyl diphosphate synthase from Arabidopsis thaliana in complex with 13-aza-13,14-dihydrocopalyl diphosphateCrystal structure of ent-copalyl diphosphate synthase from Arabidopsis thaliana in complex with 13-aza-13,14-dihydrocopalyl diphosphate

3pyb is a 3 chain structure with sequence from Arabidopsis thaliana. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:	,
Related:	3pya
Gene:	At4g02780, GA1, T5J8.9, TPSGA1 (Arabidopsis thaliana)
Activity:	Ent-copalyl diphosphate synthase, with EC number 5.5.1.13
Resources:	FirstGlance, OCA, RCSB, PDBsum

[KSA_ARATH] Catalyzes the conversion of geranylgeranyl diphosphate to the gibberellin precursor ent-copalyl diphosphate.^[1] ^[2]

↑ Prisic S, Xu J, Coates RM, Peters RJ. Probing the role of the DXDD motif in Class II diterpene cyclases. Chembiochem. 2007 May 25;8(8):869-74. PMID:17457817 doi:10.1002/cbic.200700045
↑ Mann FM, Prisic S, Davenport EK, Determan MK, Coates RM, Peters RJ. A single residue switch for Mg(2+)-dependent inhibition characterizes plant class II diterpene cyclases from primary and secondary metabolism. J Biol Chem. 2010 Jul 2;285(27):20558-63. doi: 10.1074/jbc.M110.123307. Epub 2010, Apr 29. PMID:20430888 doi:10.1074/jbc.M110.123307