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4foa

Revision as of 10:21, 25 December 2014 by OCA (talk | contribs)

Crystal Structure of the Mtb ThyA in Complex with 5-fluoro-dUMPCrystal Structure of the Mtb ThyA in Complex with 5-fluoro-dUMP

Structural highlights

4foa is a 4 chain structure with sequence from Mycobacterium tuberculosis h37rv. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:
Gene:MT2834, MTV002.29c, Rv2764c, thyA (Mycobacterium tuberculosis H37Rv)
Activity:Thymidylate synthase, with EC number 2.1.1.45
Resources:FirstGlance, OCA, RCSB, PDBsum

Function

[TYSY_MYCTU] Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity).

See Also

4foa, resolution 2.25Å

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