1e5d
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RUBREDOXIN OXYGEN:OXIDOREDUCTASE (ROO) FROM ANAEROBE DESULFOVIBRIO GIGAS
OverviewOverview
Desulfovibrio gigas is a strict anaerobe that contains a, well-characterized metabolic pathway that enables it to survive transient, contacts with oxygen. The terminal enzyme in this pathway, rubredoxin:oxygen oxidoreductase (ROO) reduces oxygen to water in a direct, and safe way. The 2.5 A resolution crystal structure of ROO shows that, each monomer of this homodimeric enzyme consists of a novel combination of, two domains, a flavodoxin-like domain and a Zn-beta-lactamase-like domain, that contains a di-iron center for dioxygen reduction. This is the first, structure of a member of a superfamily of enzymes widespread in strict and, facultative anaerobes, indicating its broad physiological significance.
About this StructureAbout this Structure
1E5D is a [Single protein] structure of sequence from [Desulfovibrio gigas] with FMN, FEO and OXY as [ligands]. Full crystallographic information is available from [OCA].
ReferenceReference
Structure of a dioxygen reduction enzyme from Desulfovibrio gigas., Frazao C, Silva G, Gomes CM, Matias P, Coelho R, Sieker L, Macedo S, Liu MY, Oliveira S, Teixeira M, Xavier AV, Rodrigues-Pousada C, Carrondo MA, Le Gall J, Nat Struct Biol. 2000 Nov;7(11):1041-5. PMID:11062560
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- Desulfovibrio gigas
- Single protein
- Carrondo, M.A.
- Coelho, R.
- Frazao, C.
- Gall, J.Le.
- Gomes, C.M.
- Liu, M.Y.
- Macedo, S.
- Matias, P.
- Oliveira, S.
- Rodrigues-Pousada, C.
- Sieker, L.
- Silva, G.
- Teixeira, M.
- Xavier, A.V.
- FEO
- FMN
- OXY
- Diiron-centre
- Flavoproteins
- Lactamase-fold
- Oxidoreductase
- Oxygenreductase