4m2x

Mycobacterium tuberculosis dihydrofolate reductase complexed with trimetrexate (TMQ)Mycobacterium tuberculosis dihydrofolate reductase complexed with trimetrexate (TMQ)

Structural highlights

4m2x is a 4 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:	, , ,
Activity:	Dihydrofolate reductase, with EC number 1.5.1.3
Resources:	FirstGlance, OCA, RCSB, PDBsum

Function

[DYR_MYCTU] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.

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OCA