Structural highlights
4l2o is a 4 chain structure with sequence from Human. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
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| Ligands: | , , , |
| Related: | 3sza, 3szb, 4l1o |
| Gene: | ALDH3, ALDH3A1 (HUMAN) |
| Activity: | Aldehyde dehydrogenase (NAD(P)(+)), with EC number 1.2.1.5 |
| Resources: | FirstGlance, OCA, RCSB, PDBsum |
Function
[AL3A1_HUMAN] ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. This protein preferentially oxidizes aromatic aldehyde substrates. It may play a role in the oxidation of toxic aldehydes.